San Jose Mercury News: Keep O’Connor, Saint Louise Hospital Beds Open It’s imperative that San Jose’s O’Connor Hospital and Gilroy’s Saint Louise Regional Hospital remain open to serve Santa Clara County’s growing population. The county already has a shortage of hospital beds. (10/4)

The Oregonian: Know The Basics About Your Health Plan Options: 2019 Medicare Guide Medicare open enrollment runs from Oct. 15 to Dec. 7. During this period, seniors 65 and older, and other Medicare enrollees, can switch providers of their comprehensive health and drug plans. Here’s a guide to some of the choices they face. (Hunsberger, 10/7)

©2019 American Association for the Advancement of Science. All rights Reserved. AAAS is a partner of HINARI, AGORA, OARE, CHORUS, CLOCKSS, CrossRef and COUNTER.Science Advances ISSN 2375-2548.

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Major benefit and advanced factors that influence the global Polyvinyl Alcohol Products market Future and present market trends that influence the growth rate and growth opportunities of the global Polyvinyl Alcohol Products market

The Hill: United States Is Undergoing A Chemical Weapons Attack Is the United States under attack from Chemical Weapons in the form of dangerous and toxic chemicals, as defined by the Chemical Weapons Convention, camouflaged as narcotics for illicit distribution resulting in death tolls rivaling those levels from the Chemical Warfare of WW I? I only see the “body count” increasing, from 13,000 deaths in 2015 to over 19,000 in 2016 and 27,000 in 2017 according to the Centers for Disease Control and NBC. That represents a 40 percent increase in each of the last few years or a doubling in two years – with no end in sight. (John M. DeMaggio, 10/7)

Politico: Marijuana Skeptics Fear ‘De Facto Legalization’ In States When Jason Nemes, a Republican legislator in deeply conservative Kentucky, proposed a bill allowing the sale of medicinal marijuana this year, he included strict conditions to prevent doctors from rampantly prescribing the drug. After all, Nemes has no interest in actually legalizing pot: He hasn’t smoked, he’s decidedly anti-drug and, until recently, he was even skeptical of marijuana’s effectiveness for treating conditions like cancer or epilepsy. (Sutton and Marinucci, 10/6)

OUTLOOK ’17: Demand key to Latin America PS, PP, PE Latin America markets are expected to grow in 2017 for polystyrene (PS), polypropylene (PP) and polyethylene (PE), but the main challenge will remain the revival of end-user demand. Several polyolefin markets also face various issues with feedstock supply, while possible mergers and acquisitions could complicate the future.

By Junmin Lee, Amr A. Abdeen, Jamila Hedhli, Kathryn L. Wycislo, Iwona T. Dobrucki, Timothy M. Fan, Lawrence W. Dobrucki, Kristopher A. Kilian

For docking studies of QoI fungicides in the Qo-binding pocket, the crystal structure of mitochondrial cytochrome bc1 enzyme complex (CYTBC1) from bovine heart bound with azoxystrobin was retrieved from the Protein Data Bank (PDB entry 1SQB). Sequence alignment of the CYTB subunit by the DNAMAN software indicated that the CYTB amino acid residues of bovine heart are similar to those of P. litchii with 83.07% sequence identity. Therefore, the crystal structure 1SQB was used as the template to study the binding conformation of four novel QoI fungicides in the Qo binding pocket. The 3D conformations of five QoI fungicides were optimized using MMFF94 force field36 with MMFF94 charge by the Sybyl 7.3 software package on the Linux platform. Docking experiments were carried out using the Surflex-Dock algorithm of the Sybyl 7.3 software. The best ligand pose was selected based on the top Surflex-Dock energy score37. Then the Qo binding pocket from “1SQB” was site-directed mutated at the detected residues including F128S, Y131C, G142A, and G142S with PyMOL software, respectively, and was minimized in energy using the MMFF94 force field. Five QoI fungicides were docked into the mutated Qo binding sites. The relationships between the mutation sites and the affinity of fungicides were analyzed based on the energy score and binding mode to the Qo binding site.

A decline in institutional secondary volumes was seen in the period, although compared to other activities, this is a relatively small element of revenue across the division.

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