"We want to produce glucaric acid in a sufficiently low-cost manner so that its full potential as a platform chemical can be fully exploited" including for creation of renewable intermediates, Darcy Prather said.

OUTLOOK ’17: US MPG to follow feedstock propylene The US monopropylene glycol (MPG) market is anticipated to remain largely stable in 2017, with pricing expected to follow the movement of feedstock propylene. Market participants said that propylene prices are generally expected to be steady-to-lower in 2017, which in turn could see MPG prices move in a corresponding manner.

OUTLOOK ’17: US soda ash production, demand rises Production from trona mines in the US increased during much of 2016, leading to a slight rise in soda-ash output. Demand for natural US soda ash in Asia is expected to increase in 2017 due to a supply crunch in the synthetic Chinese soda ash market.

· Mid-single digit Ecommerce revenue growth with owned sites expected to deliver low-teens digit revenue growth;

“One of the highlights of leading this centre is the vibrant research groups comprised of leading researchers from all over the world who are working together to develop innovative materials and technologies through advanced infrastructure and innovation in materials science research and education.

For more information on this press release visit: http://www.sbwire.com/press-releases/polyvinyl-alcohol-products-market-latest-trends-and-competitive-dynamic-by-2025-1133798.htm

We next evaluated whether synergistic interactions between FN and BMP-2 when immobilized on PEA modulate MSC osteogenesis. We have noted that Smads and ERK 1/2 act to regulate RUNX2, and Fig. 2D shows enhanced active phospho-RUNX2 (pRUNX2) expression in MSCs cultured on the synergistically presented BMP-2 environments compared to cultures using P5F3 or soluble BMP-2. These differences in pRUNX2 may result in downstream effects on the expression of osteogenic proteins regulated by RUNX2 (38). qPCR results for osteogenic markers and the corresponding immunofluorescence images were measured after 14 days of MSC culture to capture early stages of cell differentiation. Figure 2 shows that synergistic integrin/BMP-2 presentation driven by PEA led to significantly higher osteocalcin and osteonectin expression at the transcription and protein levels (Fig. 2, F and G). This system was significantly more effective than soluble administration of the GF (BMP-2 medium; Fig. 2F). Also, when the same experiments were done using PMA, where FN was adsorbed in a globular conformation, the level of cell differentiation was low and insensitive to the route used to present the GF (Fig. 2F). These results indicate that the presentation of BMP-2 in synergy with the adhesion sites on FN on PEA is more effective at triggering MSC osteoblastic differentiation compared to both the same concentration of the GF on PMA and the soluble administration of the GF. Figure 2H shows that bone-related ALP activity was higher when BMP-2 was presented bound on FN on PEA compared to the soluble administration. Figure 2H further demonstrates that blocking of BMP-2 with noggin reduced PEA-driven FN/BMP-2 osteogenic differentiation, further implicating BMP-2 signaling.

Q1: PHP invests in primary medical properties, doctors’ surgeries, it expanded its geographic footprint a couple of years ago. Can you tell us a bit more about that?

Tumor angiogenesis provides critical nutrients for cancer progression and may also facilitate pathways for dissemination during the process of metastasis. It is well established that cells that metastasize display characteristics of stem cells; however, the prevailing paradigm points to these stem-like cells residing in the hypoxic niche within the tumor interior. Controlling the geometry at the interface of a population of melanoma cells reveals a role for perimeter topology in promoting a stem-like state with enhanced tumorigenicity. We show that this putative melanoma-initiating cell (MIC) demonstrates significant enhancement in the secretion of proangiogenic molecules. This finding suggests the possibility of an “invasive niche” at the perimeter of a growing tumor that promotes a MIC state with angiogenic activity. Using several in vitro and in vivo models of tumor angiogenesis, we see concurrent stem-like characteristics with initiation of neovascularization. In the absence of hypoxia, precise topological cues induce signaling through integrin α5β1 and downstream extracellular signal–regulated kinase (ERK) signaling to regulate the MIC secretome through the signal transducer and activator of transcription (STAT) and hypoxia-inducible factor 1α (HIF1α) pathways. Inhibiting integrin α5β1 and ERK signaling attenuates both the MIC phenotype and proangiogenic signaling. These results suggest that topological cues in the periphery of malignant melanoma promote the MIC state—using mechanotransduction in lieu of low oxygen—to facilitate the formation of new vasculature for progression and invasion.

He said the anti-plasticizer can result in "a 10-time improvement in toughness to low-end-strength levels of Kevlar," a para-aramid synthetic fiber, and it can improve processability and mechanical performance. "Most plasticizers do not improve mechanical performance."

“However, the big issue for MMA producers and buyers is the lack of reliability of aging assets and aging technology that relies upon cyanide as a feedstock for the traditional acetone route,” said Marc Alvarado, associate director of syngas chemicals at IHS Markit. “Cyanide is an extremely poisonous chemical that producers would like to limit, given that commercially viable, alternative paths to MMA production exist.”

Next, we experienced strong call for Gorilla Glass for Automotive in 2018. We are capitalizing on long-term industry trends that are driving demand for technical glass. At CES, automakers confirmed the trend toward larger, longer-shaped, and more integrated displays. We also saw strong call for Corning’s industry-first auto-grade glass solutions for automotive interiors, most exclusively with customers at CES. These new solutions are making it easier and more affordable for automakers to bring curved and flat displays to market. In total, we’ve been awarded more than 55 platforms to date globally. Demand is materializing faster than we expected, and we are accelerating our investments accordingly.