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Maestrano Group PLC (LON: MNO), the open cloud business integration platform with cross-app data synchronization, today announced the appointment of Andrew Pearson as Chief Executive Officer and Managing Director.

The table below summarises the Group’s statutory reported results (where the financial highlights above are adjusted).

Significant increases in investment capability with consistent investment philosophies (public and private equity combination)

We were delighted that a number of our investment people from across the division were included in the 2018 Citywire Wealth Manager Top 100 last month, a testament to the strength of the team.

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Now, interestingly, this potential for dividend acceleration, potential or as we say is seen but not immediate, isn’t in the share price if you look at the comparisons with the past. We’re not saying that the shares are going to go up or down but there are lots of factors that affect the share price of course and the interplay is complex. If you look at history, the shares traded at typically between 10% and 15% above net asset values in the past 5 years, that was very consistent but the past year, this figures has slipped and it recently touched a premium down to 5% versus the historic NAV. By the way, we use EPRA NAV, the commonly used NAV benchmark and the dividend growth is currently steady at around 2.5% to 3% a year but that price premium has slipped.

OUTLOOK ’17: US melamine to take cues from global market The US melamine market in 2017 will take its cues from global supply and demand patterns, which will go a long way towards determining prices in the first quarter and beyond. Global demand is quite strong, and ongoing supply problems in China continue to have an impact across the world.

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OUTLOOK ’17: Brazil, Argentina to resume growing The recessions in South America’s two largest economies should end in 2017, while the prospects for Mexico will dim. Brazil should finally return to growth after two consecutive years in which GDP shrank by more than 3%. Argentina, South America’s second largest economy, should recover from the shock treatment of the reforms by its new president.

Arizona Republic: Phoenix-Area Southwest Key Migrant Child Shelter Closed After Incident The federal government has suspend operations at a Southwest Key shelter for unaccompanied migrant children in Youngtown, a spokesman for the non-profit confirmed on Friday. The Southwest Key spokesman said its Hacienda Del Sol facility was shuttered following an unspecified incident. Southwest Key reported the incident to local law enforcement, the federal government, and state regulators, spokesman Jeff Eller said. (Philip, 10/5)

We previously showed how B16F0s cultured in a spiral shape containing a high perimeter/area express higher levels of MIC markers at both convex and concave perimeter features (15). To compare angiogenesis-related gene expression for B16F0s cultured in spiral-patterned or nonpatterned gels or glass substrates, we analyzed a panel of VEGF signaling genes and genes regulated by HIF1 (Fig. 2A). The results show higher levels of expression in cells cultured on spiral-patterned gels relative to those cultured on nonpatterned gels and glass substrates. Previously, we revealed that integrin α5β1, mitogen-activated protein kinase (MAPK) pathways, and STAT activity play an important role in melanoma cancer cell plasticity, influencing their metastatic and tumorigenic characteristics when cultured in interfacial regions (15). To explore possible mechanotransduction pathways that enhance the MIC phenotype and angiogenic potential at perimeter features, we treated B16F0s with blocking antibodies to integrins α5β1 and αvβ3 and inhibitors for cytoskeletal tension (blebbistatin and Y27632), MAPK [p38, extracellular signal–regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)], bone morphogenetic proteins (BMPs) (Noggin), or glycogen synthase kinase-3 (GSK-3) (CHIR). To prevent these blocking antibodies or inhibitors from influencing hMVEC tubulogenesis, we treated B16F0s for an initial 3 days of culture, added fresh medium after washing twice with phosphate-buffered saline (PBS), and then collected the fresh conditioned medium after the remaining 2 days of culture (fig. S6A). After B16F0 conditioned medium was added to these treatments, tube formation significantly decreased with blocking antibodies to integrin α5β1 (~0.45-fold) or αvβ3 (~0.59-fold) and treatment of patterned cells with Y27632 (~0.60-fold) or ERK (~0.64-fold) (Fig. 2B). On the basis of these results, we speculate that integrin-mediated adhesion and cytoskeletal tension may augment the emergence of a MIC state and angiogenic potential. Thus, we cultured cells for 5 days on patterned gels with or without treatments (α5β1, αvβ3, Y27632, and ERK) for flow cytometric analysis to compare the expression of putative MIC markers CD271 and STAT3. Similar to the tubulogenesis results, treated cells cultured in spiral patterns show lower levels of CD271 and STAT3 compared to untreated cells (Fig. 2C). To confirm the effect of Jarid1B, which is known as a marker of MICs, we used short interfering RNA (siRNA) to silence gene expression (fig. S6B). The results show that cells cultured with Jarid1B siRNAs lead to decreased tubulogenesis as a measure of angiogenic potential (Fig. 2D). Because genes regulated by HIF1 were up-regulated for cells cultured on patterned gels, we used a HIF1α inhibitor to explore its effect on the angiogenic potential of B16F0s. Moreover, hydrocortisone and heparin sodium salt (HSS) were used because they were previously used as angiogenesis inhibitors and inducers of endothelial character. Patterned cells treated with the HIF1α inhibitor (~0.55-fold) or hydrocortisone (~0.61-fold), but not with HSS (~0.75-fold), showed a significantly reduced angiogenic potential (Fig. 2E). Together, these results confirm a role for topology at the interface of melanoma cells in promoting the MIC state and a proangiogenic secretome that promotes tubulogenesis of endothelial cells in Matrigel.

David Lai, Chairman and CEO of the Sun Chemical Supply Company, said, “Asian countries play a key role in global textile supply chains, and we are excited to deploy Applied DNA’s CertainT platform to protect our industries and consumers with reliable authentication and traceability solutions.”


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