And that leads to another large argument I have with this idea. As the quotes above show, one of the propositions behind this work is that manufacturing costs are a key barrier to the availability of drugs. But in my experience, that is rarely the case. To be sure, I have not spent my career in the generic-compound end of the industry, and the low margins in that business can make manufacturing costs more of a factor. But the barriers to generic drug availability are more often regulatory and legal ones than they are manufacturing ones. It’s true that the cost per milligram for such compounds could come down through this small-reactor technique, but only if you just need milligrams. If you need much more compound, then it becomes far less expensive to make it on scale in a defined batch and ship it somewhere.

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For cytokine analysis in the conditioned medium, we used a mouse antibody angiogenesis array membrane (24 target proteins; ab139697, Abcam) as per the manufacturer’s instructions. Conditioned medium samples were incubated with blocked membranes overnight with the membranes at 4°C. Prepared membranes were exposed to an x-ray film and developed for the protein detection. Films were scanned and analyzed using the ImageJ plug-in “Protein array analyzer” (written by G. Carpentier, 2010; http://rsb.info.nih.gov/ij/macros/toolsets/Protein%20Array%20Analyzer.txt).

Newer technologies, such as the Alpha C2 process from Lucite International, the world’s largest producer of MMA, offer an ethylene route to MMA production, avoiding the need for cyanide. Additionally, it offers a tremendous feedstock cost advantage to U.S. producers who have access to the country’s large volumes of inexpensive ethylene production. Not only does the ethylene process offer cheaper raw materials for production of MMA, but also economies of scale, particularly for producers in the U.S. and the Middle East, IHS Markit said.

· High-single digit Wholesale revenue growth with full-year revenue growth also expected to be high-single digit; and

It’s mm-scale battery, code-named Golden Hind, is designed for miniature medical implants, which account for about 50% of the current commercial opportunities in Ilika’s licensing pipeline. The cells are fabricated on standard semiconductor industry wafers usingthe company’s proprietary vacuum deposition technique. The cells are etched from the materials deposited on the wafer and singulated using standard industry back-end processing techniques. lIika has developed the materials and process technologies to make these cells on its pilot line in Southampton, UK and to align with customer demands.

4. ICBA Guidance Document to Mitigate the Potential for Benzene Formation in Beverages, International Council of Beverages Associations, 2006.

The exact same point was made in both the post you cite and this one. The availability problems are generally not those of supply. I assumed he meant an example of point-of-use in which supply is the problem. Radiolabelled compounds would be a good example, as Martin states above.

Wang, H. C., Sun, H. Y., Ma, J. X., Stammler, G. & Zhou, M. G. Fungicide effectiveness during the various developmental stages of Peronophythora litchii in vitro. J. Phytopathol. 157, 407–412 (2009).

This receptor colocalization had clear effects on subsequent cell signaling. We first examined mediators of canonical BMP-2 signaling, the Smads (small mothers against decapentaplegic), after 45 min of MSC adhesion. Smads 1, 5, and 8 are phosphorylated by BMPRIa and then translocate into the nucleus to activate RUNX2 (runt-related transcription factor 2; the osteogenic master transcription factor) (34). Results showed that Smads 1 and 5 were significantly more phosphorylated in the active state, with synergistic BMP-2 presentation on PEA (Fig. 2B). Blocking the GF-binding region of FN (FNIII12–14) with the P5F3 antibody or adding no BMP-2 reversed pSmad 1 and 5 phosphorylation to control levels, confirming that enhanced Smad signaling is due to synergistic BMP-2 presentation. To confirm this, imaging of Smads 1 and 5 (after 90 min of MSC adhesion) showed large up-regulation when BMP-2 was synergistically presented (Fig. 2D).

You’re talking about https://www.deadiversion.usdoj.gov/21cfr/21usc/843.htm ? Unless there’s some other statute, the law fully takes into account intent, listing imprinting a counterfeit marking, possessing while knowing it will be used by you or someone else for producing a controlled substance, or for export or sale to someone who will. Read: it’s fine to own one, so long as you’re not making chewable oxycontins with it, or selling drywall plaster as off-brand tylenol. If this law worked that way, GNC would be facing life in prison for selling gelatin capsules to people taking creatine without wanting to gag.

OUTLOOK ’17: Sulphur fluctuations lead to uncertainties Sulphur prices in North America moving into the New Year are somewhat uncertain, as weak phosphates markets and a recent spike in sulphur prices battle against one another. Benchmark prices have gained ground from multi-year lows earlier in 2016. Some of this is connected with stronger prices in China starting in October, which came as somewhat of a surprise to the global market.